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PCOS – metabolic and ovulatory support

Individuals with PCOS (diagnosed per guidelines), especially with insulin resistance/ovulatory dysfunction.

women

endocrine

metabolic

pcos

Support insulin sensitivity

Support ovulation/cycle regularity

Core stack

Myo-inositol

Form: powder/sachets

Dose: 2 g twice daily (total 4 g/day), often with 200 µg folic acid twice daily

morning and evening

3–6 months, then reassess

Why: Syntheses for the 2023 PCOS guideline: can be considered for metabolic and cycle outcomes; moderate/uneven evidence quality.

Cautions

Pregnancy: recent RCTs in pregnant PCOS did not reduce complications — use per indication before pregnancy
Avoid high-dose D-chiro-inositol monotherapy (potential adverse oocyte effects at high doses)

Sources

Omega-3 fatty acids (EPA+DHA)

Dose: 1–2 g/day EPA+DHA

Sources

Vitamin D (if deficient)

Dose: per 25(OH)D status (commonly 1000–2000 IU/day)

Sources

Various ‘fertility boosters’ without RCT backing: Lack of quality evidence and potential interactions.