Adults with episodic migraine looking for evidence-based nutraceutical adjuncts (coordinate with clinician).
Form: riboflavin 400 mg
Dose: 400 mg/day
With breakfast
At least 3 months
Why: Guidelines and RCTs support prophylaxis with good tolerability.
Form: elemental magnesium
Dose: 400–600 mg/day
Evening with food
8–12 weeks, then reassess
Why: Meta-analyses and trials show benefit for prevention with low risk.
Form: ubiquinone
Dose: 100–300 mg/day (split doses)
With meals
12 weeks
Why: Small RCTs and reviews suggest reduced attack frequency; well tolerated.
Dose: 3 mg at bedtime
Nightly
Notes: Some trials show prophylactic benefit; may help sleep regularity.