Adults with episodic migraine; coordinate with clinician.
Dose: 400–600 mg elemental/day
Divide BID with food
8–12 weeks before judging effect
Why: Recommended by headache societies; probable efficacy with good tolerability.
Dose: 400 mg/day
With food
12 weeks
Why: Mitochondrial support; reduced migraine days in several RCTs.
Dose: 100–300 mg/day
Split BID/TID with fat-containing meals
12 weeks
Why: Some trials suggest decreased frequency; overall evidence modest.