Peri/postmenopausal adults with vasomotor symptoms who prefer nonhormonal options.
Form: standardized soy isoflavone extract
Dose: 50 mg genistein equivalents/day
With meals
8–12 weeks
Why: Systematic reviews show modest reductions in hot flashes; endorsed as an option by NAMS 2023.
Dose: 10–20 mg/day (often 10 mg BID)
With meals
Notes: May benefit non-equol producers; smaller evidence base than isoflavones.